In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry
Yazarlar (6)
S. Gulyuz
İstanbul Teknik Üniversitesi, Türkiye
İstanbul Teknik Üniversitesi, Türkiye
U. U. Ozkose
İstanbul Teknik Üniversitesi, Türkiye
İstanbul Teknik Üniversitesi, Türkiye
P. Kocak
Yeditepe University, Türkiye
Yeditepe University, Türkiye
D. Telci
Yeditepe University, Türkiye
Yeditepe University, Türkiye
O. Yilmaz
Tubıtak Marmara Research Center, Türkiye
Tubıtak Marmara Research Center, Türkiye
Prof. Dr. Mehmet Atilla TAŞDELEN Yalova Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Express Polymer Letters (Q1) | ||
| Dergi ISSN | 1788-618X Dergi Bilgileri (2018) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2018 |
| Cilt / Sayı / Sayfa | 12 / 2 / 146–158 | DOI | 10.3144/expresspolymlett.2018.13 |
| Makale Linki | http://www.expresspolymlett.com/letolt.php?file=EPL-0008460mi=c | ||
| UAK Araştırma Alanları |
Polimer Bilimi
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| Özet |
| Synthesis and characterization of well-defined amphiphilic block copolymers containing poly (2-ethyl-2-oxazoline) as hydrophilic block and poly (ε-caprolactone) or poly (L-lactide) as hydrophobic block is achieved by copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. The clickable precursors, α-alkyne-functionalized poly (ε-caprolactone) and poly (L-lactide) and ω-azido-functionalized poly (2-ethyl-2-oxazoline) are simply prepared and joined using copper sulfate/ascorbic acid catalyst system at room temperature. The structures of precursors and amphiphilic block copolymers are characterized by spectroscopic, chromatographic and thermal analyses. The cytotoxic activities of resulting amphiphilic block copolymers and their precursors are investigated in the prostate epithelial and cancer cells under in-vitro conditions. The treatment of the healthy prostate epithelial cell line PNT1A reveals that no significant cytotoxicity, whereas some significant toxic effects on the prostate cancer cell lines are observed. |
| Anahtar Kelimeler |
| Amphiphilic block copolymers | Copper-catalyzed azide-alkyne cycloaddition click chemistry | In-vitro cytotoxic activity | Molecular engineering | Polymer synthesis | Polyoxazolines |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 35 |
| Google Scholar | 39 |