Synthesis, biocompatibility and gene encapsulation of poly(2-Ethyl 2-Oxazoline)-dioleoyl phosphatidylethanolamine (PEtOx-DOPE) and post-modifications with peptides and fluorescent dye coumarin
Yazarlar (16)
Sevgi Gulyuz
Tubıtak Marmara Research Center, Türkiye
Tubıtak Marmara Research Center, Türkiye
Duygu Bayram
Tubıtak Marmara Research Center, Türkiye
Tubıtak Marmara Research Center, Türkiye
Dr. Öğr. Üyesi Umut Ugur Ozkose Tubıtak Marmara Research Center, Türkiye
Doç. Dr. Zeynep Busra Bolat Yeditepe University, Türkiye
Polen Kocak
Yeditepe University, Türkiye
Yeditepe University, Türkiye
Dr. Öğr. Üyesi Ongun Mehmet Saka Ankara Üniversitesi, Türkiye
Burcu Devrim
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Melek Parlak Khalily
Yozgat Bozok University, Türkiye
Yozgat Bozok University, Türkiye
Dilek Telci
Yeditepe University, Türkiye
Yeditepe University, Türkiye
Prof. Dr. Fikrettin Sahin Yeditepe University, Türkiye
Doç. Dr. Salih Özçubukçu Middle East Technical University (Metu), Türkiye
Prof. Dr. Esma Sezer İstanbul Teknik Üniversitesi, Türkiye
Prof. Dr. Mehmet Atilla TAŞDELEN Yalova Üniversitesi, Türkiye
Doç. Dr. Onur Alpturk İstanbul Teknik Üniversitesi, Türkiye
Prof. Dr. Asuman Bozkır Ankara Üniversitesi, Türkiye
Öğr. Gör. Ozgur Yilmaz Tubıtak Marmara Research Center, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Polymeric Materials and Polymeric Biomaterials (Q2) | ||
| Dergi ISSN | 0091-4037 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2020 |
| Kabul Tarihi | 07-05-2020 | Yayınlanma Tarihi | 07-07-2020 |
| Cilt / Sayı / Sayfa | 70 / 1 / 1–13 | DOI | 10.1080/00914037.2020.1767617 |
| Makale Linki | http://dx.doi.org/10.1080/00914037.2020.1767617 | ||
| UAK Araştırma Alanları |
Polimer Bilimi
Nanoteknoloji
Yüzey Kimyası
|
||
| Özet |
| Liposome surface modifications serve great potential applications of liposomes, for instance, increasing stability, bioactive liposome conjugates, and targeted drug, gene, and image agent delivery. In this study, novel targeted lipopolymers, peptide 18/peptide 563-poly(2-ethyl-2-oxazoline)-dioleoylphosphatidyl-ethanolamine (P18/P563-PEtOx-DOPE), have been demonstrated to be successfully synthesized. The structures of P18/P563-PEtOx-DOPE were confirmed by FT-IR spectroscopy, GPC, and 1H-NMR. In this strategy, poly(2-ethyl 2-oxazoline)-modified liposomes were firstly constructed with molecular weights of 3,500 and 5,800 Da. Then, we chose PEtOx5800-DOPE because it has been obtained better particle size (88.74 ± 0.6816) according to the DLS results. Then, peptides- and dye-PEtOx lipid-based nanovesicle (LN) were prepared by peptide-18, peptide-563, and 7-mercapto-4-methyl coumarin … |
| Anahtar Kelimeler |
| Breast cancer | cytotoxicity | DOPE | gene encapsulation | lipopolymer | liposome | peptide | PEtOx | prostate cancer |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 14 |
| Google Scholar | 18 |