The synthesis of peptide‐conjugated poly(2‐ethyl‐2‐oxazoline)‐ b ‐poly(L‐lactide) ( PEtOx‐ b ‐PLA ) polymeric systems through the combination of controlled polymerization techniques and click reactions
Yazarlar (8)
Dr. Öğr. Üyesi Umut Uğur Özköse Piri Reis Üniversitesi, Türkiye
Sevgi Gülyüz
Tubıtak Marmara Research Center, Türkiye
Tubıtak Marmara Research Center, Türkiye
Melek Parlak Khalily
Yozgat Bozok University, Türkiye
Yozgat Bozok University, Türkiye
Doç. Dr. Salih Özçubukçu Middle East Technical University (Metu), Türkiye
Prof. Dr. Asuman Bozkır Ankara Üniversitesi, Türkiye
Prof. Dr. Mehmet Atilla TAŞDELEN Yalova Üniversitesi, Türkiye
Doç. Dr. Onur Alptürk İstanbul Teknik Üniversitesi, Türkiye
Öğr. Gör. Özgür Yılmaz Tubıtak Marmara Research Center, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Applied Polymer Science (Q2) | ||
| Dergi ISSN | 0021-8995 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2020 |
| Kabul Tarihi | 02-11-2020 | Yayınlanma Tarihi | 16-11-2020 |
| Cilt / Sayı / Sayfa | 138 / 17 / 50286–50284 | DOI | 10.1002/app.50286 |
| Makale Linki | http://dx.doi.org/10.1002/app.50286 | ||
| UAK Araştırma Alanları |
Polimer Bilimi
Nanoteknoloji
Yüzey Kimyası
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| Özet |
| To optimize the therapeutic effect of pharmaceutical agents, drug delivery systems tailored from FDA‐approved polymers like poly(L‐lactide) (PLA) is an effective strategy. Because of their hydrophobic character, these systems greatly suffer from reduced circulation time thus, amphiphilic block copolymers became favorable to overcome this limitation. Of them, poly(oxazoline)‐b‐poly(L‐lactide) are of choice as poly(oxazoline) (PEtOx) is compatible, biodegradable, while exhibiting minimum cytotoxicity. To tailor selective drug targeting drug delivery systems, whereby their selectivity for tumor tissues is maximized, these polymers should be decorated with so‐called tumor‐homing agents, such as antibodies, peptides and so forth. To this respect, we designed a new block copolymer, allyl‐poly(2‐ethyl‐2‐oxazoline)‐b‐poly(L‐lactide) allyl‐(PEtOx‐b‐PLA) and its subsequent conjugation to tumor‐homing peptides … |
| Anahtar Kelimeler |
| amphiphilic block copolymer | copper-catalysed azide-alkyne cycloaddition | peptide grafting | poly(l-lactide) | Poly(oxazoline) | thiol-ene click chemistry |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 8 |
| Google Scholar | 9 |