Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles
Yazarlar (8)
Naile Ozturk Hacettepe University
Asli Kara Hitit University
Sevgi Gulyuz
Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)
Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)
Umut Uğur Özköse Piri Reis Üniversitesi, Türkiye
Prof. Dr. Mehmet Atilla TAŞDELEN Yalova Üniversitesi, Türkiye
Asuman Bozkır Ankara Üniversitesi, Türkiye
Ozgur Yilmaz Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)
İmran Vural Hacettepe Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | JOURNAL OF MICROENCAPSULATION | ||
| Dergi ISSN | 0265-2048 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2020 |
| Kabul Tarihi | 01-07-2020 | Yayınlanma Tarihi | 13-07-2020 |
| Cilt / Sayı / Sayfa | 37 / 7 / 467–480 | DOI | 10.1080/02652048.2020.1792566 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/02652048.2020.1792566 | ||
| Özet |
| This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. Micelles were prepared with block copolymers consisting of poly(2-ethyl-2-oxazoline)--poly(ethyleneimine) (PEtOx--PEI) and poly(ε-caprolactone) (PCL) as hydrophilic and hydrophobic blocks, respectively. Doxorubicin loading, micelle size, pH-dependent drug release, and in vitro cytotoxicity on MCF-7 cells were investigated. The average size of drug-loaded micelles was under 100 nm and drug loading was between 10.7% and 48.3% (w/w). pH-sensitive drug release was more pronounced (84.7% and 68.9% (w/w) of drug was released at pH 5.0 and pH 7.4, respectively) for the micelles of the copolymer with the lowest PEI amount. The cell viability of doxorubicin-loaded micelles which were prepared by the copolymer with the lowest PEI amount was 28-33% at 72 h. PEtOx--PEI--PCL micelles of this copolymer were found to be stable and effective pH-sensitive nano-sized carriers for doxorubicin delivery. |
| Anahtar Kelimeler |
| Doxorubicin | poly(2-ethyl-2-oxazoline) | pH-sensitive release | poly(ethyleneimine) | micelles | block copolymers |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |