Özet

Modafinil is a new non-sympathomimetic drug, which is different from other central nervous system stimulators that promote wakefulness with its chemical and pharmacological properties (1). Modafinil was approved in providing wakefulness in patients who were treated for narcolepsy, or excessive sleepiness due to shift-based working or obstructing sleep apnea by the Food and Drug Agency (FDA) of United States of America (1, 2). It is reported in recent studies that there are evidences indicating that modafinil is effective in treatments of unipolar and bipolar depression, attention deficit and hyperactivity disorder, schizophrenia, obstructive sleep apnea, multiple sclerosis, Parkinson’ s disease, myotonic dystrophy, chronic fatigue syndrome, opiate intoxication, post-anesthetic fatigue, and jet-lag in addition to excessive sleepiness during daytime and narcolepsy (3). Daily recommended dose is 200-400mg/day as one or in two divided doses (4). It is believed that this article is noteworthy for a patient initiated study in antidepressive perspective of low doses modafinil (100mg/day) monotherapy.A 21 years old, male, bachelor patient, who was a worker and graduated from the primary school (5 years education), and the only child of the family, applied to our outpatient clinic with complaints of difficulty in concentration, apathy, nervousness, muscle pains, loss of enjoyment for life, unhappiness, having low spirits, and daytime sleepiness for approximately 20 days. For 3 years, he was diagnosed with depression and received different antidepressant treatments, but he did not recover. In the last year, modafinil 100mg/day was added up to his …

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Antidepressant treatment with low dose modafinil

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