Effect of low and high dose of favipiravir on ovarian and reproductive function in female rats: Biochemical and histopathological evaluation
Yazarlar (7)
Başkent Üniversitesi, Türkiye
Başkent Üniversitesi, Türkiye
Türkiye
Van Yüzüncü Yıl Üniversitesi, Türkiye
Doç. Dr. Nergis AKBAŞ
Erzincan Binali Yıldırım Üniversitesi, Türkiye
Erzincan Binali Yıldırım Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | General physiology and biophysics |
| Dergi ISSN | 1338-4325 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2022 |
| Cilt No | 41 |
| Sayı | 5 |
| Sayfalar | 457 / 463 |
| DOI Numarası | 10.4149/gpb_2022036 |
| Makale Linki | http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7846&category_id=181&option=com_virtuemart&vmcchk=1&Itemid=1 |
| Özet |
| Favipiravir is a drug which shows antiviral activity by inhibiting RNA-dependent RNA polymerase. Favipiravir causes severe adverse effects at high doses. The aim of this study was to investigate the effects of low and high dose favipiravir on ovarian and reproductive function in female rats. The rats were divided into three groups: HG group (healthy rats), FAV-100 group (rats administered 100 mg/kg favipiravir), and FAV-400 group (rats administered 400 mg/kg favipiravir) with 12 rats in each group. Favipiravir was administered orally twice daily for 1 week. Six rats from each group were euthanized and their ovaries were removed. Oxidative and antioxidant parameters were measured in ovarian tissues and examined histopathologically. The remaining animals were kept to breed. Animals receiving favipiravir had increased oxidant content, decreased antioxidant activity, decreased histopathological damage, infertility, and gestational delay. Favipiravir treatment should be used with caution, especially in women of reproductive age. |
| Anahtar Kelimeler |
| Favipiravir | Ovarian tissue | Reproductive function |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 6 |