Exploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Lupus (Q3)
Dergi ISSN	0961-2033 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	İngilizce	Basım Tarihi	08-2024
Kabul Tarihi	–	Yayınlanma Tarihi	26-08-2024
Cilt / Sayı / Sayfa	33 / 12 / 1358–1364	DOI	10.1177/09612033241279071
Makale Linki	https://doi.org/10.1177/09612033241279071
UAK Araştırma Alanları	Kur’An-I Kerim Okuma ve Kıraat İlmi

Özet

Objective Systemic lupus erythematosus (SLE) constitutes an autoimmune disorder with potential involvement of the gastrointestinal system (GIS). Our objective was to assess the gastrointestinal (GI) manifestations in patients diagnosed with childhood onset SLE. Methods The study cohort consisted of 123 patients with childhood onset-SLE and GIS involvement from 16 referral departments of pediatric rheumatology. All participants met the Systemic Lupus International Collaborating Clinics criteria. Results Out of 123 patients, 78 (63.4%) exhibited GIS involvement at the initial SLE diagnosis, whereas the remaining 45 (36.6%) developed GI symptoms after a median duration of 12 (3–140) months. Eighty-two (66.7%) individuals experienced symptoms related to the GI tract, whereas the remaining patients received a diagnosis of GI involvement through laboratory assessments. The predominant initial GIS involvement symptom was abdominal pain, observed in 77 (62.6%) patients, followed by elevated hepatic transaminases in 70 (56.9%), hepatomegaly in 40 (32.5%), diarrhea in 26 (21.1%), and jaundice in 11 (8.9%) patients. The GIS involvement was associated with SLE in 82 (78.6%), while it resulted from drug-related adverse events in 35 (28.5%) patients or comorbidities in 6 (0.5%) patients. Conclusion GIS involvement should be considered in all childhood onset-SLE patients, especially in the presence of suggestive symptoms or elevated hepatic transaminases. It is also crucial to consider SLE in the differential diagnosis of GIS manifestations in children. Apart from GIS involvement directly associated with SLE, adverse events of drugs should be kept in mind.

Anahtar Kelimeler

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları

Exploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study

Dergi Adı	LUPUS
Yayıncı	SAGE Publications Ltd
Açık Erişim	Hayır
ISSN	0961-2033
E-ISSN	1477-0962
CiteScore	4,1
SJR	0,779
SNIP	0,756

Exploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study

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