Therapeutic effect of Berberis vulgaris fruit extract on histopathological changes and oxidative stress markers of ovarian ischemia and reperfusion injury in rats
Yazarlar (15)
Serdar Yigit Kafkas University, Türkiye
Dr. Öğr. Üyesi İsa YEŞİLYURT Kafkas University, Türkiye
Soner Bitiktas Kafkas University, Türkiye
Pinar Aksu Kilicle Kafkas University, Türkiye
Lale Duysak Ataturk University, Türkiye
Muhammed Yayla Kafkas University, Türkiye
Erdem Toktay Kafkas University, Türkiye
Nilnur Eyerci Kafkas University, Türkiye
Seyit Ali Bingol Kafkas University, Türkiye
Arzu Gezer Ataturk University, Türkiye
Fatma Necmiye Kaci
Erzurum Technical University, Türkiye
Erzurum Technical University, Türkiye
Ergin Taskin Agri Ibrahim Cecen University, Türkiye
Gul Esma Akdogan
Kafkas University, Türkiye
Kafkas University, Türkiye
Hasan Cilgin
Kafkas University, Türkiye
Kafkas University, Türkiye
Ali Alper Kahraman
Kafkas University, Türkiye
Kafkas University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | JOURNAL OF KING SAUD UNIVERSITY SCIENCE (Q1) | ||
| Dergi ISSN | 1018-3647 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2024 |
| Cilt / Sayı / Sayfa | 36 / 11 / – | DOI | 10.1016/j.jksus.2024.103578 |
| Makale Linki | https://doi.org/10.1016/j.jksus.2024.103578 | ||
| Özet |
| Aim: This study aimed to investigate the possible protective effect of berberine, the active compound of Berberis vulgaris plant extract, which has anti-inflammatory and antioxidant properties, in an ovarian ischemia-reperfusion model by utilizing molecular, biochemical, and histopathological methods. Methods: In this experimental study, 42 adolescent female Sprague Dawley rats (6 weeks old) were divided into 7 equal groups. Under anesthesia, ischemia was induced by ligating the bilateral adnexal tissues, and after 3 h of ischemia, reperfusion was achieved by removing the adnexal ligation. Berberis vulgaris extract was administered by oral gavage 1 h after ischemia for the ischemia groups and 1 h before reperfusion for the ischemia + reperfusion groups. After 3 h of reperfusion, the experiment was terminated. Results: The administration of Berberis vulgaris extract decreased the hemorrhagic areas, reduced the number of TUNEL-positive cells, and decreased CYC1 immunoreactivity levels in histopathological analysis compared to the groups subjected to ischemia or ischemia + reperfusion without the plant extract. CAT, SOD, and GSH increased due to Berberis vulgaris administration while MDA levels decreased. Berberis vulgaris also downregulated TNF-alpha levels compared to the ischemia and ischemia + reperfusion groups. Conclusion: Berberis vulgaris extract may have a protective effect against ovarian ischemia-reperfusion injury. Further molecular studies are needed to clarify this protective effect. |
| Anahtar Kelimeler |
| Berberis vulgaris | TNF-alpha | Ischemia | Reperfusion | Ovarian |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |