Naturally acquired hepatitis A antibodies after haematopoetic stem cell transplantation
Yazarlar (9)
S. S. Yalçin
Hacettepe Üniversitesi, Türkiye
M. Kondolot
Hacettepe Üniversitesi, Türkiye
H. Göker
Hacettepe Üniversitesi, Türkiye
B. Kuşkonmaz
Hacettepe Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yasemin KARACAN
Hacettepe Üniversitesi, Türkiye
M. Çetin
Hacettepe Üniversitesi, Türkiye
S. Aksu
Hacettepe Üniversitesi, Türkiye
I. Tezcan
Hacettepe Üniversitesi, Türkiye
D. Uçkan
Hacettepe Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Epidemiology and Infection | ||
| Dergi ISSN | 0950-2688 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2011 |
| Cilt / Sayı / Sayfa | 139 / 5 / 683–687 | DOI | 10.1017/S0950268810001585 |
| Özet |
| Haematopoietic stem cell transplant (HSCT) recipients lose immune memory of exposure to infectious agents and vaccines accumulated throughout their lifetime and therefore need to be revaccinated. We aimed to evaluate the influence of different factors on hepatitis A virus (HAV) immunity in both child and adult HSCT recipients living in an intermediate endemic region, Turkey. Eighty patients (age range 2·5-57 years) who had HAV serology prior to HSCT were evaluated. The prevalence of HAV seropositivity was 85% (n=68) before HSCT. There was no history of HAV vaccination before HSCT in children and HAV vaccine was not available in Turkey 10 years ago, so it was assumed that all seropositive patients reflected natural immunity. After the exclusion of six patients with autologous HSCT, the remaining 62 seropositive and allogeneic patients were included in this retrospective study. The duration of HAV seropositivity was estimated using the Kaplan-Meier method, log-rank analysis and Cox regression models. Estimated mean time to loss of HAV seropositivity was 48·6 months after transplantation. Patients who were older (≥18 years) at transplantation and who had older (≥18 years) donors became seronegative later (P<0·05). Cox backward-stepwise regression confirmed that older age of recipient at transplantation was the only significant parameter for HAV seropositivity (P<0·05). HAV-inactivated vaccine might be recommended later to older HSCT recipients in intermediate endemic regions. © Copyright Cambridge University Press 2010. |
| Anahtar Kelimeler |
| follow-up serology | Hepatitis A | HSCT | seroprevalence |
Science Direct
Naturally acquired hepatitis A antibodies after haematopoetic stem cell transplantation
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 4 |