The performance of various serum parameters in blood during the first trimester in the early detection of pre-eclampsia
Yazarlar (5)
Yaprak Engin-Ustun
Sağlık Bilimleri Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
Dr. Öğr. Üyesi Arife AKAY ACEMOĞLU Sağlık Bilimleri Üniversitesi
Müjde Can İbanoğlu
Sağlık Bilimleri Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
Büşra Demir Çendek
T.C. Sağlık Bakanlığı, Türkiye
T.C. Sağlık Bakanlığı, Türkiye
Tuğba Ağbal
T.C. Sağlık Bakanlığı, Türkiye
T.C. Sağlık Bakanlığı, Türkiye
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | Journal of health sciences and medicine (Online) | ||
| Dergi ISSN | 2636-8579 | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2024 |
| Cilt / Sayı / Sayfa | 7 / 4 / 451–458 | DOI | 10.32322/jhsm.1500190 |
| Makale Linki | https://doi.org/10.32322/jhsm.1500190 | ||
| UAK Araştırma Alanları |
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| Özet |
| Aims: The aim of this study is to examine the alterations in various serum parameters within the circulatory system throughout the first trimester and assess their efficacy in identifying pre-eclampsia at an early stage. Methods: This retrospective analysis undertook an examination of the medical records pertaining to 225 pregnancies that met the eligibility criteria at a tertiary referral center, spanning the years 2018 to 2021. Furthermore, an examination of laboratory parameters during the first trimester was performed, which included neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune inflammation index, systemic inflammation response index, pan-immune inflammation value, AST-to-platelet ratio index, delta neutrophil index, and prognostic nutritional index (PNI). A receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for inflammatory and nutritional biomarkers to predict early- onset pre-eclampsia. Results: The group of individuals with early-onset pre-eclampsia displayed notably elevated levels of neutrophil, lymphocyte, PCT, MPV, ALT, and creatinine, while displaying significantly reduced levels of albumin, bilirubin, PLR, MLR, and PNI (p<0.05, for all). The statistical significance of the area under the curve for PNI, albumin, PLR, MLR, and bilirubin values was observed to be greater than 0.5 (p<0.05, for all). Conclusion: This article is the first to examine the efficacy of the first trimester PNI value in early detection of pre-eclampsia patients. According to this study, PNI, albumin, PLR, MLR, and bilirubin show potential as useful indicators for predicting the likelihood of developing pre-eclampsia at an early stage in the first trimester. |
| Anahtar Kelimeler |
| Serum markers | pregnancy | first trimester | high-risk | pre-eclampsia |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| TR Dizin | 2 |