The Effect of Aerobic Exercise Training on Patients with Type III Spinal Muscular Atrophy
Yazarlar (10)
Sezan Mergen Kilic İstanbul Tıp Fakültesi, Türkiye
Prof. Dr. Fatma MUTLUAY Yalova Üniversitesi, Türkiye
Arman Cakar İstanbul Tıp Fakültesi, Türkiye
Murat Giris İstanbul Tıp Fakültesi, Türkiye
Hacer Durmus İstanbul Tıp Fakültesi, Türkiye
Ilknur Bingul İstanbul Tıp Fakültesi, Türkiye
Asuman Gedikbasi Istanbul Üniversitesi, Türkiye
Canan Kucukgergin İstanbul Tıp Fakültesi, Türkiye
Zehra Oya Uyguner İstanbul Tıp Fakültesi, Türkiye
Yesim Parman
İstanbul Tıp Fakültesi, Türkiye
İstanbul Tıp Fakültesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Clinical Medicine (Q1) | ||
| Dergi ISSN | 2077-0383 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2025 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 28-08-2025 |
| Cilt / Sayı / Sayfa | 14 / 17 / – | DOI | 10.3390/jcm14176087 |
| Makale Linki | https://www.mdpi.com/2077-0383/14/17/6087 | ||
| Özet |
| Background Spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by variants in the SMN1 gene. This study investigates the functional and biochemical effects of moderate-intensity aerobic exercise in SMA Type III patients. Methods Twenty-three patients aged 18–57 years were included in this study. The training group underwent a 12-week aerobic exercise program using a bicycle ergometer at 60–70% of their maximum heart rate three times per week for 30 min per session. The training continued for an additional four months. The primary outcome measures were the six-minute walk distance and oxygen uptake, both reflecting exercise capacity. Secondary outcome measures included muscle strength with dynamometer, functional performance, and fatigue with different scales. Furthermore, serum survival motor neuron (SMN) protein and insulin-like growth factor-1 (IGF-1) hormone levels were measured at baseline, post-training first measurement (after 12 weeks), and post-training second measurement (after 28 weeks). Results The exercise group showed a significant increase in exercise capacity (p < 0.001) and 6MWT walking distance (p = 0.003). Furthermore, reduction in walking time in the 10-m walk test (p = 0.019) and improvements in strength of the right and left quadriceps (p = 0.004, p = 0.031) and right gastrocnemius (p = 0.034) muscles were identified. Furthermore, an improvement in the Fatigue Severity Scale (FSS) (p = 0.037) was found. SMN protein and IGF-1 levels were increased in the second measurement in the training group (p = 0.022 and p = 0.016, respectively). Conclusions An aerobic exercise … |
| Anahtar Kelimeler |
| aerobic exercise | exercise capacity | functional performance | IGF-1 | neuromuscular disorders | physiotherapy | SMA Type III | SMN protein |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 2 |
| Scopus | 1 |