The Therapeutic Effects of Bioactive Compounds on Colorectal Cancer via PI3K/Akt/mTOR Signaling Pathway: A Critical Review
Yazarlar (5)
Kübra Demir Istanbul Health & Technology University, Türkiye
Arş. Gör. Rana Turgut Istanbul Health & Technology University, Türkiye
Selcen Şentürk Istanbul Health & Technology University, Türkiye
Dr. Öğr. Üyesi Handan IŞIKLAR Yalova Üniversitesi, Türkiye
Doç. Dr. Elif Günalan Istanbul Health & Technology University, Türkiye
| Makale Türü |
Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği,
araştırma notu, bilirkişi raporu ve benzeri)
(SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not,
editöre mektup, tartışma, vaka takdimi ve özet türünden makale)
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| Dergi Adı | Food Science and Nutrition (Q2) | ||
| Dergi ISSN | 2048-7177 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2024 |
| Kabul Tarihi | 28-09-2024 | Yayınlanma Tarihi | 07-11-2024 |
| Cilt / Sayı / Sayfa | 12 / 12 / 9951–9973 | DOI | 10.1002/fsn3.4534 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.4534 | ||
| UAK Araştırma Alanları |
Beslenme ve Diyetetik
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| Özet |
| Understanding the molecular signaling pathways of colorectal cancer (CRC) can be accepted as the first step in treatment strategy. Permanent mTOR signaling activation stimulates the CRC process via various biological processes. It supplies the survival of CRC stem cells, tumorigenesis, morbidity, and decreased response to drugs in CRC pathogenesis. Therefore, inhibition of the mTOR signaling by numerous bioactive components may be effective against CRC. The study aims to discuss the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. The potential molecular effects of bioactive compounds on the mTOR pathway's upstream and downstream targets are examined. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest … |
| Anahtar Kelimeler |
| alkaloids | colorectal cancer | polyphenols | terpenoids |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 10 |
| Web of Science | 22 |
| Scopus | 22 |
| Google Scholar | 26 |