Injectable and self-healing dual crosslinked gelatin/kappa-carrageenan methacryloyl hybrid hydrogels via host-guest supramolecular interaction for wound healing
Yazarlar (6)
Dilara Yilmaz-Aykut
Harvard Medical School, Amerika Birleşik Devletleri
Harvard Medical School, Amerika Birleşik Devletleri
Gulsah Torkay
İstinye Üniversitesi, Türkiye
İstinye Üniversitesi, Türkiye
Doç. Dr. Alper KAŞGÖZ Yalova Üniversitesi, Türkiye
Su Ryon Shin
Harvard Medical School, Amerika Birleşik Devletleri
Harvard Medical School, Amerika Birleşik Devletleri
Ayca Bal-Ozturk
İstinye Üniversitesi, Türkiye
İstinye Üniversitesi, Türkiye
Huseyin Deligoz Istanbul University-Cerrahpasa, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Biomedical Materials Research Part B Applied Biomaterials (Q3) | ||
| Dergi ISSN | 1552-4973 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2023 |
| Kabul Tarihi | 10-06-2023 | Yayınlanma Tarihi | 23-06-2023 |
| Cilt / Sayı / Sayfa | 111 / 11 / 1921–1937 | DOI | 10.1002/jbm.b.35295 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.b.35295?casa_token=DKtF5N45SekAAAAA%3Azp9AgYehGz7_AIrtjOW0UVOnHvhk8atLMoLzjBgpbj7pJarwf4bJOKWyKkeBLby_DtEJXjNHQ-Xbnd8 | ||
| Özet |
| Injectable hydrogels based on natural polymers have shown great potential for various tissue engineering applications, such as wound healing. However, poor mechanical properties and weak self‐healing ability are still major challenges. In this work, we introduce a host‐guest (HG) supramolecular interaction between acrylate‐β‐cyclodextrin (Ac‐β‐CD) conjugated on methacrylated kappa‐carrageenan (MA‐κ‐CA) and aromatic residues on gelatin to provide self‐healing characteristics. We synthesize an MA‐κ‐CA to conjugate Ac‐β‐CD and fabricate dual crosslinked hybrid hydrogels with gelatin to mimic the native extracellular matrix (ECM). The dual crosslinking occurs on the MA‐κ‐CA backbone through the addition of KCl and photocrosslinking process, which enhances mechanical strength and stability. The hybrid hydrogels exhibit shear‐thinning, self‐healing, and injectable behavior, which apply easily … |
| Anahtar Kelimeler |
| dual crosslinking | gelatin/kappa-carrageenan | host-guest interaction | self-healing hydrogel | wound healing |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 13 |
| Scopus | 13 |