Injectable and self-healing dual crosslinked gelatin/kappa-carrageenan methacryloyl hybrid hydrogels via host-guest supramolecular interaction for wound healing
Yazarlar (6)
Dilara Yilmaz-Aykut
Harvard Medical School, Amerika Birleşik Devletleri
Gulsah Torkay
İstinye Üniversitesi, Türkiye
Doç. Dr. Alper KAŞGÖZ
Yalova Üniversitesi, Türkiye
Su Ryon Shin
Harvard Medical School, Amerika Birleşik Devletleri
Ayca Bal-Ozturk
İstinye Üniversitesi, Türkiye
Huseyin Deligoz
Istanbul University-Cerrahpasa, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Biomedical Materials Research Part B Applied Biomaterials (Q3) | ||
| Dergi ISSN | 1552-4973 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2023 |
| Cilt / Sayı / Sayfa | 111 / 11 / 1921–1937 | DOI | 10.1002/jbm.b.35295 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.b.35295?casa_token=DKtF5N45SekAAAAA%3Azp9AgYehGz7_AIrtjOW0UVOnHvhk8atLMoLzjBgpbj7pJarwf4bJOKWyKkeBLby_DtEJXjNHQ-Xbnd8 | ||
| Özet |
| Injectable hydrogels based on natural polymers have shown great potential for various tissue engineering applications, such as wound healing. However, poor mechanical properties and weak self-healing ability are still major challenges. In this work, we introduce a host-guest (HG) supramolecular interaction between acrylate-β-cyclodextrin (Ac-β-CD) conjugated on methacrylated kappa-carrageenan (MA-κ-CA) and aromatic residues on gelatin to provide self-healing characteristics. We synthesize an MA-κ-CA to conjugate Ac-β-CD and fabricate dual crosslinked hybrid hydrogels with gelatin to mimic the native extracellular matrix (ECM). The dual crosslinking occurs on the MA-κ-CA backbone through the addition of KCl and photocrosslinking process, which enhances mechanical strength and stability. The hybrid hydrogels exhibit shear-thinning, self-healing, and injectable behavior, which apply easily under a minimally invasive manner and contribute to shear stress during the injection. In-vitro studies indicate enhanced cell viability. Furthermore, scratch assays are performed to examine cell migration and cell–cell interaction. It is envisioned that the combination of self-healing and injectable dual crosslinked hybrid hydrogels with HG interactions display a promising and functional biomaterial platform for wound healing applications. |
| Anahtar Kelimeler |
| dual crosslinking | gelatin/kappa-carrageenan | host-guest interaction | self-healing hydrogel | wound healing |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 11 |
| SCOPUS | 13 |
| Google Scholar | 13 |