Therapeutic effect of Berberis vulgaris fruit extract on histopathological changes and oxidative stress markers of ovarian ischemia and reperfusion injury in rats
Yazarlar (15)
Serdar Yiğit Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi İsa YEŞİLYURT Kafkas Üniversitesi, Türkiye
Soner Bitiktaş Kafkas Üniversitesi, Türkiye
Pınar Aksu Kılıçle Kafkas University, Türkiye
Lale Duysak Ataturk University, Türkiye
Muhammed Yayla Selçuk Üniversitesi, Türkiye
Erdem Toktay Kafkas University, Türkiye
Nilnur Eyerci Kafkas University, Türkiye
Seyit Ali Bingöl Kafkas Üniversitesi, Türkiye
Arzu Gezer Ataturk University, Türkiye
Fatma Necmiye Kacı
Erzurum Technical University, Türkiye
Erzurum Technical University, Türkiye
Engin Taşkın Türkiye
Gül Esma Akdoğan Karadağ Türkiye
Hasan Çılgın
Kafkas University, Türkiye
Kafkas University, Türkiye
Ali Alper Kahraman Kafkas University
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of King Saud University - Science (Q1) | ||
| Dergi ISSN | 1018-3647 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 12-2024 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-12-2024 |
| Cilt / Sayı / Sayfa | 36 / 11 / 103578–0 | DOI | 10.1016/j.jksus.2024.103578 |
| Makale Linki | https://doi.org/10.1016/j.jksus.2024.103578 | ||
| Özet |
| Aim: This study aimed to investigate the possible protective effect of berberine, the active compound of Berberis vulgaris plant extract, which has anti-inflammatory and antioxidant properties, in an ovarian ischemia-reperfusion model by utilizing molecular, biochemical, and histopathological methods. Methods: In this experimental study, 42 adolescent female Sprague Dawley rats (6 weeks old) were divided into 7 equal groups. Under anesthesia, ischemia was induced by ligating the bilateral adnexal tissues, and after 3 h of ischemia, reperfusion was achieved by removing the adnexal ligation. Berberis vulgaris extract was administered by oral gavage 1 h after ischemia for the ischemia groups and 1 h before reperfusion for the ischemia + reperfusion groups. After 3 h of reperfusion, the experiment was terminated. Results: The administration of Berberis vulgaris extract decreased the hemorrhagic areas, reduced the number of TUNEL-positive cells, and decreased CYC1 immunoreactivity levels in histopathological analysis compared to the groups subjected to ischemia or ischemia + reperfusion without the plant extract. CAT, SOD, and GSH increased due to Berberis vulgaris administration while MDA levels decreased. Berberis vulgaris also downregulated TNF-alpha levels compared to the ischemia and ischemia + reperfusion groups. Conclusion: Berberis vulgaris extract may have a protective effect against ovarian ischemia-reperfusion injury. Further molecular studies are needed to clarify this protective effect. |
| Anahtar Kelimeler |
| Berberis vulgaris | TNF-alpha | Ischemia | Reperfusion | Ovarian |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |